Phenylacetic acid

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Phenyl acetate (or phenylacetate) is a carboxylic acid ester that has been found in the biofluids of patients with nephritis and/or hepatitis as well as patients with phenylketonuria (PKU) an inborn error of metabolism.

Phenyl acetate (or phenylacetate) is a carboxylic acid ester that has been found in the biofluids of patients with nephritis and/or hepatitis as well as patients with phenylketonuria (PKU) an inborn error of metabolism. Excess phenylalanine in the body can be disposed of through a transamination process leading to the production of phenylpyruvate. The phenylpyruvate can be further metabolized into a number of products. Decarboxylation of phenylpyruvate gives phenylacetate while a reduction reaction gives phenyllactate. The phenylacetate can be further conjugated with glutamine to give phenylacetyl glutamine. All of these metabolites can be detected in serum and urine of PKU patients. Phenyl acetate is also produced endogenously as the metabolite of 2-Phenylethylamine which is mainly metabolized by monoamine oxidase to form phenyl acetate. 2-phenylethylamine is an "endogenous amphetamine" which may modulate central adrenergic functions and the urinary phenyl acetate levels have been postulated as a marker for depression. Phenylacetate is also found in essential oils e.g. neroli rose oil free and as esters' and in many fruits. As a result it is used as a perfumery and flavoring ingredient.

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Proteasome/Ubiquitin

Endogenous Metabolite

Human Endogenous Metabolite

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103-82-2

136.15

C8H8O2

>98% (HPLC)

DMSO:10 mM

OC(=O)Cc1ccccc1

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(-20℃)

With Ice Pack

≥ 2 years